By V. I. Ivanov, N. A. Liapunova (auth.), Professor Dr. Günter Obe (eds.)
Utilized genetic study, genetic toxicology and mutation learn examine the mutagenicity and cancerogenicity of chemical substances and different brokers. everlasting mutation in genes and chromosomes, could be triggered by way of aplethora of brokers, together with ionizing and nonionizing radiations, chemical compounds, and viruses. one of the features discused through Advances in Mutagenesis learn are (1) the knowledge of the molecular mechanisms resulting in mutations, and (2) the prevention of a inconsiderate creation of mutagenic brokers into the surroundings. Contents: Nikolay W. Timofeeff-Ressovsky (1900-1981): An Essay on his existence and clinical Achievements. - Arylnitrenium Ions and the Genotoxic efficiency of fragrant Amines and Nitro Compounds. - Analysisof Mutagenicity and Chemical constitution in a variety of sequence of similar Compounds. - Formation of 8-Hydroxyguanine by way of Oxidative DNA harm, its fix and its Mutagenic results. - Exploring Genetic and Non-Genetic Relationships: The Induction of Micronuclei. - Mechanisms of triggered Mutagenesis by means of Ultraviolet mild in Escherichia coli. - Polytene Chromosomes in Mutagenesis. Three-Way Differential Stainingof Chromosomes for the id of SCEs in keeping with cellphone Cycle: basics and purposes. - The Mammalian Centromere: Centromere Separation, Kinetochore Proteins and Aneuploidy. - Chorionic Villi research. - ExploringGenetic and Non-Genetic Relationships: The Induction of Micronuclei.
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Extra info for Advances in Mutagenesis Research
These data suggest that it is possible to predict the carcinogenicities of oxygen radical forming chemicals and their target organs in rats from the levels of oh 8 Gua in DNA in various organs after their administration. 3 Repair of oh 8 Gua Residues in DNA If the formation of oh 8 Gua is really a biologically significant type of DNA damage, cells must have a repair enzyme(s) for it. After whole body irradiation of mice with y-ray, the oh 8 Gua formed in liver DNA decreased with time, Formation of 8-Hydroxyguanine by Oxidative DNA Damage 35 3 ,------------------, en o Fig.
These studies were, however, unable to single out the role of the nitrenium ion and distinguish it from the roles of the other intermediates and their reactions. 6 The Contribution of the Organism to the Genotoxic Potency The preceding section focused on the genotoxic potency of a series of compounds in a given organism and therefore did not consider the possible influence of the organism on the results. This influence can be revealed in studies on the genotoxic potency of a compound or group of compounds in several organisms.
LIIC. Academic Press, San Diego, pp 681-710 Tokiwa H, Ohnishi Y (1986) Mutagenicity and carcinogenicity of nitroarenes and their sources in the environment. CRC Crit Rev Toxicol 17:23-60 Vance W A, Levin DE (1984) Structural features of nitro aromatics that determine mutagenic activity in Salmonella lyphimurium. Environ Mutagen 6:797-811 30 D. Wild: Arylnitrenium Ions and the Genotoxic Potency Vance W A, Okamoto HS, Wang Yi Y (1986) Structure-activity relationships of nitro and methylnitro derivatives of indo line, indole, indazole and benzimidazole in Salmonella typhimurium.
Advances in Mutagenesis Research by V. I. Ivanov, N. A. Liapunova (auth.), Professor Dr. Günter Obe (eds.)